Royal Air Force Typhoon fighter aircraft have conducted a mission with French warplanes in a coordinated attack targeting an subterranean weapons facility in Syria used by the IS group, as stated by the UK's MoD.
The location, located using reconnaissance, was thought to be containing munitions and bombs, the announcement noted, and was positioned in mountainous terrain just above Palmyra in Syria's central region.
"Our aircraft employed Paveway IV guided bombs to strike a number of access tunnels down to the site... preliminary assessments are that the objective was successfully hit," the ministry announced.
There was no sign of any civilian impact in the strike late on Saturday and every plane involved made a safe return, the defence officials confirmed.
The Typhoon fighters were backed up by a Voyager refuelling tanker.
IS - also known as Daesh - imposed militant control over parts of Syria and Iraq prior to its 2019 collapse.
"This operation shows British leadership, and resolve to operate in unison with allied nations, to stamp out any re-emergence of IS and their violent and radical beliefs in the region," Britain's Defence Chief John Healey said.
RAF aircraft have performed patrols over Syria to "prevent any efforts to regroup" of the group after its routing at the Baghuz confrontation in the year 2019, the MoD reported.
"I must thank every member of British forces involved in this operation for their professionalism and their courage," the Defence Secretary added. "They were among a great many British personnel deployed over Christmas and New Year. This mission, to eliminate militants who threaten our safety, demonstrates how British military are ready to step up, all year round, ensuring Britain's security within its borders and influential overseas."
Last December, the American forces conducted what it called a "large-scale strike" against Islamic State objectives in the country, after an attack killed two US servicemembers and a local interpreter in the Palmyra area.
The U.N. estimates Daesh still maintains an estimated 5,000 to 7,000 militants in Syria and Iraq.